Other Targetable Sarcomas
نویسندگان
چکیده
منابع مشابه
Other targetable sarcomas.
Despite complex genetics, aneuploid tumors like dedifferentiated liposarcoma have specific and reproducible chromosomal changes such as amplification of HDM2 and CDK4 that represent potential targets for systemic therapy. In addition, there are cancer cell survival pathways that may not be the target of chromosomal translocations or mutations that are still estimable targets for new systemic th...
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Although benign hemangiomas are among the most common diagnoses among connective tissue tumors, angiosarcomas and other sarcomas arising from blood vessels are rare, even among sarcomas. Because endothelial tumors have unique embryonal derivation compared with other sarcomas, it is not surprising they have unique characteristics. Herein are reviewed some of these unique characteristics and ther...
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We aimed to identify the incidence, outcome and prognostic factors associated with spindle cell sarcomas of bone (SCSB). We studied 196 patients with a primary non-metastatic tumour treated with the intent to cure. The results were compared with those of osteosarcoma patients treated at our hospital during the same period. The overall incidence of SCSB was 7.8% of all patients with a primary bo...
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Despite extensive research efforts over the past two decades to identify effective agents for the treatment of soft tissue sarcomas, few agents are available, and with modest utility. There is a high unmet medical need to develop novel therapies for the treatment of patients with soft tissue sarcomas. Clinical trials for soft tissue sarcomas should be optimally designed, and it is crucial that ...
متن کاملDrug repositioning in sarcomas and other rare tumors
The exploration and identification of new anti-cancer therapeutic indications for an approved drug already in use, or for a drug that was shelved for non-safety reasons in early clinical development, represents an attractive alternative to the costly, time-consuming and inefficient process of developing novel anticancer agents. Drug repositioning or repurposing can bypass the discovery and earl...
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ژورنال
عنوان ژورنال: Seminars in Oncology
سال: 2009
ISSN: 0093-7754
DOI: 10.1053/j.seminoncol.2009.06.008